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KMID : 1098420070150040271
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Korean Journal of Medicinal Crop Science
2007 Volume.15 No. 4 p.271 ~ p.275
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Inhibitory Effect of Extracts from Woody Plants on Tumor Necrosis Production in Lipopolysaccharide-Stimulated RAW264.7 cells
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Cho Jae-Youl
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Abstract
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Naturally occurring substances are important biomedical resources with low toxicity and ethnopharmacology-based efficacy. Four out of 45 extracts (Celastrus orbiculatus, Cercis chinensis, Stephanadra incisa, and Weigela subsessilis) prepared from the bark of Korea Forest plants exhibited more than 50% of inhibition on production in lipopolysaccharide (LPS)-activated RAW264.7 cells at . In particular, potential inhibitory components of 4 extracts showed more than 50% inhibition seemed to be concentrated in methylene chloride (MC) fraction from C. orbiculatus, in ethyl acetate (EtOAc) fraction from C. chinensis and in hexane (Hx) fraction from S. incisa, whereas inhibitory activities of W. subssilis were broadly seen in non-polar solvent fractions such as Hx, MC and EtOAc. Therefore, our results suggest that extracts from C. orbiculatus, C. chinensis, S. incisa and W. subsessilis may be developed as a therapeutic remedy against diseases such as rheumatoid arthritis or further fractionated to isolate active components having inhibitory activity.
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KEYWORD
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Korea forest plant, In vitro screening, TNF-α production, macrophage-like cells
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